Endocrine Abstracts

Introduction: Leydig cell hypoplasia (LCH) is a rare autosomal recessive condition that interferes with normal development of male external genitalia in 46,XY individuals. It is mediated by mutations in the luteinizing hormone receptor gene (LHCGR), most frequently located in the coding sequence, resulting in impairment of either LH/CG binding or signal transduction.Case report: We report a 32-year-old female which presented with primary amenorrhea, fema...

Background: Parathyroid hormone (PTH) secretion in response to hypocalcemia was found to be altered in people living with HIV (PLWH) and HIV infection has therefore been acknowledged as a potential reason for hypoparathyroidism (HPO).Aim: To describe the prevalence of HPO in a population of PLWH.Methods: Monocentric, retrospective sub-study of the Munich ArcHIV cohort.Results: 579 patients (461 men (79.6%)) w...

Purpose: To investigate the kinetics of adrenocorticotropin (ACTH) following oral metyrapone administration and describe differences between ACTH-deficient and non ACTH-deficient subjects.Methods: Patients from a tertiary endocrine center at a University Hospital in Munich, Germany, were tested. Metyrapone (Metopirone, HRA Pharma, France) was administered with a dosage of 40 mg/kg bodyweight at 0800 h. Consecutive levels of ACTH were determined at 0, 60,...